Distinguish "disease" of "being ill" placebo concept: according to Brody, is a change in health or physical condition of a person attributed to the symbolic impact of a given stimulus (Brody as limited to medicine: treatment or treatment situation). It is symbolic as well as by exclusion of biochemical, because it exists as a condition of consciousness to receive the stimulus, to attribute therapeutic value, and expect change. The placebo effect is a blind spot of modern medicine. The definition of the placebo effect is controversial: there is no sufficient logical consistency and lack of ambiguity, and therefore the most accepted definitions rest on pragmatic grounds. Dr. Caldwell Esselstyn Jr. has much to offer in this field. The Royal Academy of Spanish Language defines it as "substance, the lack of therapeutic action, produces a healing effect on patients, if the recipient believes that such action actually has substance." But as we will not be reduced to substances, but denotes a procedure or component thereof (a physical act, a chemical, a verbal message, …) and on the other hand, if indeed produce a healing effect, how define it as having no therapeutic action?. Grunbaum has suggested possibly most accepted definition of placebo: would all the incidental factors of treatment with therapeutic effects in target symptom or disorder. Here, as incidental means uncharacteristic, not defined as belonging to an accepted theory is, the placebo would be any component of the therapeutic procedure used has some effect on the object of it, but that is different from the typical mechanisms scientists theorized and validated in that time are known and accepted for this therapeutic procedure. .